Article
Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes.
Nature cancer - 1 Oct 2022
Sengupta Satyaki, Das Sanjukta, Crespo Angela C, Cornel Annelisa M, Patel Anand G, Mahadevan Navin R, Campisi Marco, Ali Alaa K, Sharma Bandana, Rowe Jared H, Huang Hao, Debruyne David N, Cerda Esther D, Krajewska Malgorzata, Dries Ruben, Chen Minyue, Zhang Shupei, Soriano Luigi, Cohen Malkiel A, Versteeg Rogier, Jaenisch Rudolf, Spranger Stefani, Romee Rizwan, Miller Brian C, Barbie David A, Nierkens Stefan, Dyer Michael A, Lieberman Judy, George Rani E
Abstract excerpt
Apart from the anti-GD2 antibody, immunotherapy for neuroblastoma has had limited success due to immune evasion mechanisms, coupled with an incomplete understanding of predictors of response. Here, from bulk and single-cell transcriptomic analyses, we identify a subset of neuroblastomas enriched for transcripts associated with immune activation and inhibition and show that these are predominantly characterized by...
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