Article

Reciprocal impacts of telomerase activity and tumor cell differentiation in neuroblastoma tumor biology

2021-05-10

Abstract excerpt

Telomere maintenance and tumor cell differentiation have been separately implicated in neuroblastoma malignancy. Their mechanistic connection is unclear. We analyzed neuroblastoma cell lines and morphologic subclones representing the adrenergic (ADRN) and mesenchymal (MES) differentiation states and uncovered sharp differences in their telomere protein and telomerase activity levels. Pharmacologic conversion of AD...

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Literature Corpus work: 5c6d63a5-0329-5295-9375-d0ef1192e313
DOI: 10.1101/2021.05.09.442765

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