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Article

Lineage dependence of the neuroblastoma surfaceome defines tumor cell state-dependent and -independent immunotherapeutic targets

17 Jan 2025

Abstract excerpt

BACKGROUND: Neuroblastoma is a heterogeneous disease with adrenergic (ADRN)-like cells and therapy-resistant mesenchymal (MES)-like cells driven by distinct transcription factor networks. Here, we investigate the expression of immunotherapeutic targets in each neuroblastoma subtype and propose pan-neuroblastoma and cell state-specific targetable cell surface proteins. METHODS: We characterized cell lines,...

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PMID: 39825754
DOI: 10.1093/neuonc/noaf012

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