Article

Benzoate and Salicylate Tolerant Strains Lose Antibiotic Resistance during Laboratory Evolution of <i>Escherichia coli</i> K-12

2016-07-11

Abstract excerpt

<h4>ABSTRACT</h4> Escherichia coli K-12 W3110 grows in the presence of membrane-permeant organic acids that can depress cytoplasmic pH and accumulate in the cytoplasm. We conducted experimental evolution by daily diluting cultures in increasing concentrations of benzoic acid (up to 20 mM) buffered at external pH 6.5, a pH at which permeant acids concentrate in the cytoplasm. By 2,000 generations, clones isolated...

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Literature Corpus work: b78d4d1b-8a88-5b83-8ab3-2fa9a5304b4e
DOI: 10.1101/063271

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