Genome-wide screening of the Keio collection identifies genetic determinants of Escherichia coli sensitivity and tolerance to benzoic acid.

Abstract excerpt

Benzoic acid (BA) is a widely used weak-acid preservative, yet the genome-scale mechanisms underlying bacterial adaptation to preservative stress in food-associated environments remain incompletely defined. In this study, we screened the Escherichia coli Keio single-gene mutant line to identify genes associated with altered BA sensitivity or tolerance. Mutants were evaluated on LB agar containing 0.70-1.00 mg/mL...

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