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Article

Stimulation of Slack K(+) Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex.

Cell reports - 30 Aug 2016

Fleming Matthew R, Brown Maile R, Kronengold Jack, Zhang Yalan, Jenkins David P, Barcia Gulia, Nabbout Rima, Bausch Anne E, Ruth Peter, Lukowski Robert, Navaratnam Dhasakumar S, Kaczmarek Leonard K

Abstract excerpt

Human mutations in the cytoplasmic C-terminal domain of Slack sodium-activated potassium (KNa) channels result in childhood epilepsy with severe intellectual disability. Slack currents can be increased by pharmacological activators or by phosphorylation of a Slack C-terminal residue by protein kinase C. Using an optical biosensor assay, we find that Slack channel stimulation in neurons or transfected cells...

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Share to Biosensing Techniques
Share to Bridged Bicyclo Compounds, Heterocyclic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fragile X Mental Retardation Protein

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Identifiers

PMID: 27545877
DOI: 10.1016/j.celrep.2016.07.024
PMCID: PMC5123741

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