Article

A CK2α–G3BP1 signaling axis regulates local translation in developing neurons and is disrupted in OCNDS

2026-08-17

Abstract excerpt

<h4>ABSTRACT</h4> Neurodevelopmental disorders are frequently caused by mutations in pleiotropic kinases, yet downstream effectors driving neuronal pathology remain undefined. Here, we identify the G3BP1-dependent stress granule pathway as the dominant effector of casein kinase 2 (CK2α) in developing neurons, implying that its dysregulation underlies the neurodevelopmental deficits of Okur-Chung neurodevelopmenta...

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Literature Corpus work: 2c0b8955-0d88-514f-915f-a4ca2151a6c9
DOI: 10.64898/2026.08.11.744218

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