Article
Phactr1 regulates Slack (KCNT1) channels via protein phosphatase 1 (PP1).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2020
Ali Syed Rydwan, Malone Taylor Joseph, Zhang Yalan, Prechova Magdalena, Kaczmarek Leonard Konrad
Abstract excerpt
The Slack (KCNT1) gene encodes sodium-activated potassium channels that are abundantly expressed in the central nervous system. Human mutations alter the function of Slack channels, resulting in epilepsy and intellectual disability. Most of the disease-causing mutations are located in the extended cytoplasmic C-terminus of Slack channels and result in increased Slack current. Previous experiments have shown that...
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