Article

Mitochondrial dysfunction as a hallmark of brain senescence in telomerase-deficient mice

2026-08-28

Abstract excerpt

Neurodegenerative diseases, including Alzheimer's disease (AD), are strongly associated with aging. However, the molecular mechanisms underlying pathological brain aging remain incompletely understood. In this study, we used a mouse model of telomere attrition, a major driver of cellular senescence, to perform an unbiased analysis of how telomere-driven senescence affects cellular physiology and contributes to pro...

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Literature Corpus work: b7662849-7237-58fe-942a-ae9166e08356
DOI: 10.64898/2026.08.25.746691

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