Article
Somatic mutations in TBX3 promote hepatic clonal expansion by accelerating VLDL secretion.
The Journal of clinical investigation - 16 Sept 2025
Mannino Gregory, Quinn Gabriella, Zhu Min, Wang Zixi, Wang Xun, Li Boyuan, Hsieh Meng-Hsiung, Mathews Thomas, Zacharias Lauren, Gu Wen, Gopal Purva, Brzozowska Natalia, Campbell Peter, Hoare Matt, Liszczak Glen, Zhu Hao
Abstract excerpt
Somatic mutations that increase clone fitness or resist disease are positively selected, but the impact of these mutations on organismal health remains unclear. We previously showed that Tbx3 deletion increases hepatocyte fitness within fatty livers. Here, we detected TBX3 somatic mutations in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). In mice, Tbx3 deletion protected against,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.