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Article

Germline mutations and somatic mosaicism in steatotic liver diseases and related liver carcinogenesis.

Nature reviews. Gastroenterology & hepatology - 1 Jun 2026

Trépo Eric, Zucman-Rossi Jessica, Nault Jean-Charles

Abstract excerpt

Steatotic liver diseases, encompassing metabolic dysfunction-associated steatotic liver disease and alcohol-related liver disease, affect nearly one-third of the global population and are a leading cause of cirrhosis and hepatocellular carcinoma. The substantial interindividual variation in disease progression indicates important genetic contributions beyond environmental factors. Genome-wide association studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41680342
DOI: 10.1038/s41575-026-01175-y

Genes

CIDEB
FOXO1
GPAM
PNPLA3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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