Article

The structure and evolutionary diversity of the fungal E3-binding protein

2022-04-20

Abstract excerpt

The pyruvate dehydrogenase complex (PDC) is a central metabolic enzyme in all living cells composed majorly of E1, E2, and E3. Tight coupling of their reactions makes each component essential, so that loss impacts oxidative metabolism pathologically. E3 retention is mediated by the E3-binding protein (E3BP), which has not previously been clearly resolved within the PDC. Here, the structure of the fungal E3BP in co...

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Literature Corpus work: b74f5379-3fda-516a-b76e-1f840272b612
DOI: 10.1101/2022.04.20.488913

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