Article
Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesis.
Molecular cell - 8 Jan 2015
Stefely Jonathan A, Reidenbach Andrew G, Ulbrich Arne, Oruganty Krishnadev, Floyd Brendan J, Jochem Adam, Saunders Jaclyn M, Johnson Isabel E, Minogue Catherine E, Wrobel Russell L, Barber Grant E, Lee David, Li Sheng, Kannan Natarajan, Coon Joshua J, Bingman Craig A, Pagliarini David J
Abstract excerpt
The ancient UbiB protein kinase-like family is involved in isoprenoid lipid biosynthesis and is implicated in human diseases, but demonstration of UbiB kinase activity has remained elusive for unknown reasons. Here, we quantitatively define UbiB-specific sequence motifs and reveal their positions within the crystal structure of a UbiB protein, ADCK3. We find that multiple UbiB-specific features are poised to...
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