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Article

Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex.

Structure (London, England : 1993) - 1 Mar 2006

Brautigam Chad A, Wynn R Max, Chuang Jacinta L, Machius Mischa, Tomchick Diana R, Chuang David T

Abstract excerpt

The 9.5 MDa human pyruvate dehydrogenase complex (PDC) utilizes the specific dihydrolipoamide dehydrogenase (E3) binding protein (E3BP) to tether the essential E3 component to the 60-meric core of the complex. Here, we report crystal structures of the binding domain (E3BD) of human E3BP alone and in complex with human E3 at 1.6 angstroms and 2.2 angstroms, respectively. The latter structure shows that residues...

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Source

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Identifiers

PMID: 16442803
DOI: 10.1016/j.str.2006.01.001
PMCID: PMC2879633

Genes

PDC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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