Article

Protein-protein interfaces as druggable targets: A common motif of the pyridoxal-5’-phosphate-dependent enzymes to receive the coenzyme from its producers

2023-02-13

Abstract excerpt

Pyridoxal-5’-phosphate (PLP), a phosphorylated form of vitamin B6, acts as a coenzyme for numerous reactions, including those changed in cancer and/or associated with the disease prognosis. Since highly reactive PLP may modify cellular proteins, it is hypothesized to be directly transferred from its donors to acceptors. Our goal is to validate the hypothesis by finding common motif(s) in a multitude of the PLP-dep...

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Literature Corpus work: 449fa7ef-35d5-5a50-a20e-44ccd8c6974c
DOI: 10.1101/2023.02.13.528268

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Protein-protein interfaces as druggable targets: A common motif of the pyridoxal-5’-phosphate-dependent enzymes to receive the coenzyme from its producersDOI 10.1101/2023.02.13.528268Read

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