Article

Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia and causes myeloproliferative disease in mice via altered <i>Runx1</i> splicing

2021-02-06

Abstract excerpt

<h4>Summary</h4> Acute myeloid leukemia (AML) is driven by numerous molecular events that contribute to disease progression. Herein, we identified hnRNP K overexpression as a recurrent abnormality in AML that is associated with inferior patient outcomes. In murine hematopoietic stem and progenitor cells, hnRNP K overexpression altered self-renewal and differentiation potential. Furthermore, murine transplantation...

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Literature Corpus work: b73d23ad-d918-5740-8982-f78af0644559
DOI: 10.1101/2021.02.05.429385

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