Article

The heterogeneity of the DNA damage response landscape determines patient outcomes in ovarian cancer

2021-08-05

Abstract excerpt

Defective DNA damage response (DDR) pathways allow cancer cells to accrue genomic aberrations and evade normal cellular growth checkpoints. Defective DDR also determines response to chemotherapy. However, the interaction and overlap between the two double strand repair pathways and the three single strand repair pathways is complex, and has remained poorly understood. Here we show that, in ovarian cancer, a diseas...

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Literature Corpus work: b738773b-164a-58b6-8e20-89bfdff0caae
DOI: 10.1101/2021.08.03.454868

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