Article

RepairSwitch: simultaneous functional assessment of homologous recombination vs end joining DNA repair pathways in living cells

2023-01-17

Abstract excerpt

<h4>ABSTRACT</h4> DNA repair pathways are frequently defective in human cancers. DNA double strand breaks (DSBs) are most often repaired by either homologous recombination (HR) or non-homologous end joining (NHEJ). Alterations in repair pathways can indicate sensitivity to therapeutic agents such as PARP inhibitors, cisplatin, and immunotherapy. Thus, functional assays to measure rates of HR and NHEJ are of signi...

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Literature Corpus work: 05511b78-3740-5ba4-b98c-fdad0c8edf9e
DOI: 10.1101/2023.01.17.524235

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