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Participation of the ATR/CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancer

21 Apr 2020

Abstract excerpt

Ovarian cancer is one of the most lethal gynecologic malignancies reported throughout the world. The initial, standard-of-care, adjuvant chemotherapy in epithelial ovarian cancer is usually a platinum drug, such as cisplatin or carboplatin, combined with a taxane. However, despite surgical removal of the tumor and initial high response rates to first-line chemotherapy, around 80% of women will develop cancer...

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PMID: 32316968
DOI: 10.1186/s13045-020-00874-6

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