Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced repair of DNA interstrand crosslinking in ovarian cancer cells from patients following treatment with platinum-based chemotherapy

11 Sept 2007

Abstract excerpt

Despite high tumour response rates to platinum-based chemotherapy in ovarian cancer survival is poor due to the emergence of drug resistance. Mechanistic studies in clinical material have been hampered by the unavailability of sensitive methods to detect the critical drug-induced effects in individual cells. A modification of the single cell gel electrophoresis (comet) assay allows the sensitive detection of DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to DNA Repair Mechanisms
Share to Ovarian cancer diagnosis and treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17848946
DOI: 10.1038/sj.bjc.6603973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced repair of DNA interstrand crosslinking in ovarian cancer cells from patients following treatment with platinum-based chemotherapyPMID 17848946Read ↗

The heterogeneity of the DNA damage response landscape determines patient outcomes in ovarian cancerSemantic proximity Read ↗

DNA damage and repair measured by comet assay in cancer patientsSemantic proximity Read ↗

Comet assay measures of DNA damage as biomarkers of irinotecan response in colorectal cancer in vitro and in vivo.Semantic proximity Read ↗

Role of platinum-DNA adduct formation and removal in cisplatin resistance in human ovarian cancer cell linesSemantic proximity Read ↗

Multiple end‐point analysis reveals cisplatin damage tolerance to be a chemoresistance mechanism in a NSCLC model: Implications for predictive testingSemantic proximity Read ↗

The epigenetic response to platinum-induced DNA damage and repairSemantic proximity Read ↗

DNA damage and repair in human lymphocytes exposed to three anticancer platinum drugsSemantic proximity Read ↗

Human mesenchymal stem cells are resistant to cytotoxic and genotoxic effects of cisplatin in vitroSemantic proximity Read ↗

A Gynecologic Oncology Group Study of Platinum-DNA Adducts and Excision Repair Cross-Complementation Group 1 Expression in Optimal, Stage III Epithelial Ovarian Cancer Treated with Platinum-Taxane ChemotherapySemantic proximity Read ↗

Detection of oxaliplatin-induced DNA crosslinks in vitro and in cancer patients using the alkaline comet assaySemantic proximity Read ↗

Hypoxia prevents etoposide-induced DNA damage in cancer cells through a mechanism involving hypoxia-inducible factor 1Semantic proximity Read ↗

Genetic instability in bladder cancer assessed by the comet assay.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.