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Article

DNA damage repair in ovarian cancer: unlocking the heterogeneity

20 Jun 2018

Abstract excerpt

Treatment for advanced ovarian cancer is rarely curative; three quarters of patients with advanced disease relapse and ultimately die with resistant disease. Improving patient outcomes will require the introduction of new treatments and better patient selection. Abrogations in the DNA damage response (DDR) may allow such stratifications.A defective DNA-damage response (DDR) is a defining hallmark of high grade...

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PMID: 29925418
DOI: 10.1186/s13048-018-0424-x

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