Article

TRANsCre-DIONE transdifferentiates scar-forming reactive astrocytes into functional motor neurons

2020-07-25

Abstract excerpt

<h4>SUMMARY</h4> In spinal cord injury (SCI), the scar-forming reactive astrocytes with upregulated GFAP proliferate aberrantly near the injury site, allowing themselves as a prime target for transdifferentiation into neurons to replenish dead neurons. However, the conventional use of GFAP promoter to target reactive astrocytes has two inherent problems: inadvertent conversion of normal astrocytes and low effici...

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Literature Corpus work: b731a99c-a3a7-5951-8d6c-f55a513a4cab
DOI: 10.1101/2020.07.24.215160

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