Article

Regeneration of dorsal spinal cord neurons after injury via <i>in situ</i> NeuroD1-mediated astrocyte-to-neuron conversion

2019-10-31

Abstract excerpt

Spinal cord injury (SCI) often leads to impaired motor and sensory functions, partially because the injury-induced neuronal loss cannot be easily replenished through endogenous mechanisms. In vivo neuronal reprogramming has emerged as a novel technology to regenerate neurons from endogenous glial cells by forced expression of neurogenic transcription factors. We have previously demonstrated successful astrocyte-t...

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Literature Corpus work: f8249082-0c65-5f17-a492-5f0cfbde4aed
DOI: 10.1101/818823

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