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Article

Direct reprogramming of human astrocytes into neural stem cells and neurons

8 Mar 2012

Abstract excerpt

Generating neural stem cells and neurons from reprogrammed human astrocytes is a potential strategy for neurological repair. Here we show dedifferentiation of human cortical astrocytes into the neural stem/progenitor phenotype to obtain progenitor and mature cells with a neural fate. Ectopic expression of the reprogramming factors OCT4, SOX2, or NANOG into astrocytes in specific cytokine/culture conditions...

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PMID: 22426197
DOI: 10.1016/j.yexcr.2012.02.040

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