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Article

Generation of Human iPSC-Derived Astrocytes with a mature star-shaped phenotype for CNS modeling.

Stem cell reviews and reports - 1 Oct 2022

Voulgaris Dimitrios, Nikolakopoulou Polyxeni, Herland Anna

Abstract excerpt

The generation of astrocytes from human induced pluripotent stem cells has been hampered by either prolonged differentiation-spanning over two months-or by shorter protocols that generate immature astrocytes, devoid of salient mature astrocytic traits pivotal for central nervous system (CNS) modeling. We directed stable hiPSC-derived neuroepithelial stem cells to human iPSC-derived Astrocytes (hiAstrocytes) with...

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Identifiers

PMID: 35488987
DOI: 10.1007/s12015-022-10376-2
PMCID: PMC9489586

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