Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia.

doi:10.1002/ajmg.b.32560

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Oct 2017

Leonenko Ganna, Richards Alexander L, Walters James T, Pocklington Andrew, Chambert Kimberly, Al Eissa Mariam M, Sharp Sally I, O'Brien Niamh L, Curtis David, Bass Nicholas J, McQuillin Andrew, Hultman Christina, Moran Jennifer L, McCarroll Steven A, Sklar Pamela, Neale Benjamin M, Holmans Peter A, Owen Michael J, Sullivan Patrick F, O'Donovan Michael C

Abstract excerpt

Risk of schizophrenia is conferred by alleles occurring across the full spectrum of frequencies from common SNPs of weak effect through to ultra rare alleles, some of which may be moderately to highly penetrant. Previous studies have suggested that some of the risk of schizophrenia is attributable to uncommon alleles represented on Illumina exome arrays. Here, we present the largest study of exomic variation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Exome

Share to Follow-Up Studies

Share to Fragile X Mental Retardation Protein

Share to Genome-Wide Association Study

Share to Prognosis

Share to Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 28719003
DOI: 10.1002/ajmg.b.32560
PMCID: PMC5669020

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation intolerant genes and targets of FMRP are enriched for nonsynonymous alleles in schizophrenia.PMID 28719003Read ↗

Rare schizophrenia risk variants are enriched in genes shared with neurodevelopmental disordersSemantic proximity Read ↗

The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability.Semantic proximity Read ↗

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.Semantic proximity Read ↗

A polygenic burden of rare disruptive mutations in schizophrenia.Semantic proximity Read ↗

Exome arrays capture polygenic rare variant contributions to schizophrenia.Semantic proximity Read ↗

Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia.Semantic proximity Read ↗

Loss-of-function variants in schizophrenia risk and SETD1A as a candidate susceptibility gene.Semantic proximity Read ↗

Genetic association of FMRP targets with psychiatric disordersSemantic proximity Read ↗

Rare schizophrenia risk variant burden is conserved in diverse human populationsSemantic proximity Read ↗

Exome sequencing in families with severe mental illness identifies novel and rare variants in genes implicated in Mendelian neuropsychiatric syndromesSemantic proximity Read ↗

Genome-wide burden of deleterious coding variants increased in schizophrenia.Semantic proximity Read ↗

De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.