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Complex Genetics in Pancreatitis: Insights Gained From a New Candidate Locus Panel.

Pancreas - 1 Aug 2020

Ellison Mitchell A, Spagnolo Daniel M, Shelton Celeste, Orlova Ekatarina, LaRusch Jessica, Whitcomb David C, Haupt Mark

Abstract excerpt

OBJECTIVES: Chronic pancreatitis is the end stage of a pathologic inflammatory syndrome with multiple etiological factors, including genetic. We hypothesized that some pancreatitis etiology originates in pancreatic acinar or duct cells and requires both injury and compensatory mechanism failure. METHODS: One hundred pancreatitis patients were assessed using a DNA sequencing panel for pancreatitis. Cooccurrence of...

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PMID: 32658084
DOI: 10.1097/MPA.0000000000001612

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