Comparison of clinical features and pancreatic cancer risk between genetic mutations associated versus alcohol associated chronic pancreatitis.

doi:10.1016/j.pan.2025.10.011

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Article

Comparison of clinical features and pancreatic cancer risk between genetic mutations associated versus alcohol associated chronic pancreatitis.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Feb 2026

Lee Yoonchan, Song Tae Jun, Cho Sung Hyun, Huh Gunn, Oh Dongwook, Seo Dong-Wan

Abstract excerpt

BACKGROUND/OBJECTIVES: Genetic mutations associated chronic pancreatitis (GCP), caused by pathogenic variants in SPINK1, PRSS1, or CFTR, represents a distinct subset of chronic pancreatitis, whereas alcoholic chronic pancreatitis (ACP) is the predominant adult etiology. We compared the clinical course and pancreatic cancer risk between GCP and ACP. METHODS: This retrospective cohort included GCP patients from a...

Topics

Humans
Pancreatic Neoplasms
Male
Female
Adult
Trypsin Inhibitor, Kazal Pancreatic
Middle Aged
Mutation
Pancreatitis, Chronic
Pancreatitis, Alcoholic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Retrospective Studies

Cystic Fibrosis Transmembrane Conductance Regulator

Trypsin

Risk Factors

Genetic Predisposition to Disease

Trypsinogen

Aged

Source

Open in PubMed

Identifiers

PMID: 41198504
DOI: 10.1016/j.pan.2025.10.011

Genes

SPINK1
CFTR
PRSS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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