Article
Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis.
Cell stem cell - 6 Aug 2026
Osorio-Vasquez Victoria, Zhu Jonathan, Lumibao Jan C, Lande Kathryn, Peck Kristina L, Stamp McKenna K, Okhovat Shira R, Song Hyemin, Ogawa Satoshi, Kubota Casie S, Pantazopoulou Vasiliki, Curtis Kassidy, Kuo Kahing, Dai Yang, Rock Angelica, Bottomley Chelsea R, Thomas Ethan J, Hsu Jasper, Herrera Morales Araceli, Fowler Alexandra, McGriff T'Onj, Evensen K Garrett, Williams April E, Larsen Siri, Abdulla Muhamad, Greer Phil, Gibson Jessica, Downes Michael, Evans Ronald M, Lowy Andrew M, Whitcomb David C, Zou Jingjing, Molinolo Alfredo, Oh Tae Gyu, White Rebekah R, Bellin Melena, Tiriac Hervé, Engle Dannielle D
Abstract excerpt
Chronic pancreatitis (CP) affects ∼3 million people worldwide, yet altering the course of the disease is challenging. We developed a patient-derived organoid (PDO) platform to investigate the molecular pathogenesis of this disease and identify therapeutic strategies. We generated 37 PDOs from patients with idiopathic, hereditary, and alcohol-related CP with a high genetic concordance. PDOs retained...
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