Article

Defining unique structural features in the MAFA and MAFB transcription factors that control <i>Insulin</i> gene activity

2023-08-23

Abstract excerpt

<h4>ABSTRACT</h4> MAFA and MAFB are related basic-leucine-zipper domain containing transcription factors which have important overlapping and distinct regulatory roles in a variety of cellular contexts, including hormone production in pancreatic islet α and β cells. Here we first examined how mutating conserved MAF protein-DNA contacts obtained from X-ray crystal structure analysis impacted their DNA-binding and...

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Literature Corpus work: 945bda20-0141-5276-92dc-f27bec529a33
DOI: 10.1101/2023.08.23.554429

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