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Article

Genome-wide variants and polygenic risk scores for cognitive impairment following blood or marrow transplantation.

Bone marrow transplantation - 1 Jun 2022

Sharafeldin Noha, Zhang Jianqing, Singh Purnima, Bosworth Alysia, Chen Yanjun, Patel Sunita K, Wang Xuexia, Francisco Liton, Forman Stephen J, Wong F Lennie, Ojesina Akinyemi I, Bhatia Smita

Abstract excerpt

Cognitive impairment is prevalent in blood or marrow transplantation (BMT) recipients, albeit with inter-individual variability. We conducted a genome-wide association study of objective cognitive function assessed longitudinally in 239 adult BMT recipients for discovery and replicated in an independent cohort of 540 BMT survivors. Weighted genome-wide polygenic risk scores (PRS) were constructed using linkage...

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Identifiers

PMID: 35379913
DOI: 10.1038/s41409-022-01642-5
PMCID: PMC9233077

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