Article

Dysregulated Wnt Signaling in Parkinson’s Disease: Correlation with Motor and Nonmotor Symptom Severity

2025-11-12

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Dysregulation of Wnt signaling and neuroinflammation are critically implicated in Parkinson’s disease (PD) pathogenesis. This study investigates the clinical utility of key circulating biomarkers related to these pathways for diagnosing PD and correlating with symptom severity. <bold>Methods</bold> In this case-control study, 90 PD patients and 45 healthy co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b6ce28c4-9865-5483-89da-f2365fbbdfdb
DOI: 10.21203/rs.3.rs-7919099/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dysregulated Wnt Signaling in Parkinson’s Disease: Correlation with Motor and Nonmotor Symptom SeverityDOI 10.21203/rs.3.rs-7919099/v1Read

Identification of necroptosis-related genes in Parkinson’s disease by integrated bioinformatics analysis and experimental validationSemantic proximity Read

High‐mobility group box 1 in Parkinson's disease: from pathogenesis to therapeutic approachesSemantic proximity Read

Serum kynurenine and beta-alanine levels are associated with Wnt pathway gene expression in leukocytes of patients with Parkinson's diseaseSemantic proximity Read

Autophagic signatures in peripheral blood mononuclear cells from Parkinson's disease patientsSemantic proximity Read

Discovery and validation of biomarkers for Parkinson’s disease from human cerebrospinal fluid using mass spectrometry-based proteomics analysisSemantic proximity Read

Dysregulated Wnt and NFAT signaling in a Parkinson’s disease LRRK2 G2019S knock-in modelSemantic proximity Read

Dysregulated Wnt and NFAT signaling in a Parkinson's disease LRRK2 G2019S knock-in model.Semantic proximity Read

Circulating Inflammatory miRNAs Associated with Parkinson’s Disease PathophysiologySemantic proximity Read

Prospective role of PAK6 and 14-3-3γ as biomarkers for Parkinson’s diseaseSemantic proximity Read

Differential tear fluid miRNAs in patients with Parkinson’s disease and atypical Parkinsonian syndromesSemantic proximity Read

Sex differences in peripheral and central dysregulation of the kynurenine pathway in Parkinson’s diseaseSemantic proximity Read

Accelerometry-Derived REM Sleep Behavior Disorder Predicts Future Parkinson’s Disease in the UK BiobankSemantic proximity Read