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Sex differences in peripheral and central dysregulation of the kynurenine pathway in Parkinson’s disease

6 May 2025

Abstract excerpt

We previously demonstrated that kynurenine pathway (KP) dysregulation associates with Parkinson's disease (PD) and its symptoms. Here, we profiled 16 KP-related markers in a second, independent cohort; plasma: n = 202 (116 PD ("OFF"), 86 controls); CSF: n = 183 (108, 75). Consistent with previous findings, we detected significantly higher concentrations of neurotoxic 3-hydroxykynurenine in plasma and lower...

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PMID: 40328760
DOI: 10.1038/s41531-025-00949-6

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