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Article

Autophagic signatures in peripheral blood mononuclear cells from Parkinson's disease patients

25 Dec 2024

Abstract excerpt

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor impairments and the accumulation of misfolded α-synuclein. Dysregulation of the autophagy-lysosomal pathway (ALP), responsible for degrading misfolded proteins, has been implicated in PD pathogenesis. However, current diagnostic approaches rely heavily on motor symptoms, which occur due to substantial neurodegeneration,...

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PMID: 39730076
DOI: 10.1016/j.mocell.2024.100173

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