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Article

Designing drugs and chemical probes with the dualsteric approach.

Chemical Society reviews - 11 Dec 2023

Zha Jinyin, He Jixiao, Wu Chengwei, Zhang Mingyang, Liu Xinyi, Zhang Jian

Abstract excerpt

Traditionally, drugs are monovalent, targeting only one site on the protein surface. This includes orthosteric and allosteric drugs, which bind the protein at orthosteric and allosteric sites, respectively. Orthosteric drugs are good in potency, whereas allosteric drugs have better selectivity and are solutions to classically undruggable targets. However, it would be difficult to simultaneously reach high potency...

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PMID: 37990599
DOI: 10.1039/d3cs00650f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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