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Establishment of a second-generation transgenic marmoset model of polyglutamine disease recapitulating neurological symptoms and pathology

2025-03-13

Abstract excerpt

Neurodegenerative diseases, including polyglutamine diseases, remain a major clinical challenge, partly because of limited animal models that recapitulate human disease. Here, we describe a second-generation transgenic marmoset model of spinocerebellar ataxia 3 (SCA3), a polyglutamine disease, which stably expresses expanded CAG repeats in ATXN3 . All five offspring of the founder marmoset harbored the transgene...

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Literature Corpus work
b6b2bf42-e879-5be6-a9e3-4231140d0d6f
DOI
10.1101/2025.03.12.642922
Open publication

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Establishment of a second-generation transgenic marmoset model of polyglutamine disease recapitulating neurological symptoms and pathologyDOI 10.1101/2025.03.12.642922
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