Article
Establishment of a second-generation transgenic marmoset with germline transmission that models polyglutamine disease.
Disease models & mechanisms - 1 Oct 2025
Minakawa Eiko N, Owari Kensuke, Nogami Naotake, Nakatani Terumi, Koizumi Masashi, Kawanobe Akiyo, Saga Yosuke, Kudo Moeko, Noguchi Satoru, Hanakawa Takashi, Hori Yuki, Numazawa Hidemi, Takeuchi Toshihide, Katakai Yuko, Saito Ryoichi, Nagai Yoshitaka, Saito Yuko, Tomioka Ikuo, Seki Kazuhiko
Abstract excerpt
Neurodegenerative diseases, including polyglutamine diseases, remain a clinical challenge, partly because of limited animal models that recapitulate human disease. Here, we describe a second-generation transgenic marmoset model of spinocerebellar ataxia 3 (SCA3), a polyglutamine disease, which stably expresses expanded CAG repeats in ataxin 3 (ATXN3). All five offspring of the founder marmoset harbored the...
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