Transgenic Monkey Model of the Polyglutamine Diseases Recapitulating Progressive Neurological Symptoms.

doi:10.1523/ENEURO.0250-16.2017

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Article

Transgenic Monkey Model of the Polyglutamine Diseases Recapitulating Progressive Neurological Symptoms.

eNeuro - 1 Jan 2000

Tomioka Ikuo, Ishibashi Hidetoshi, Minakawa Eiko N, Motohashi Hideyuki H, Takayama Osamu, Saito Yuko, Popiel H Akiko, Puentes Sandra, Owari Kensuke, Nakatani Terumi, Nogami Naotake, Yamamoto Kazuhiro, Noguchi Satoru, Yonekawa Takahiro, Tanaka Yoko, Fujita Naoko, Suzuki Hikaru, Kikuchi Hisae, Aizawa Shu, Nagano Seiichi, Yamada Daisuke, Nishino Ichizo, Ichinohe Noritaka, Wada Keiji, Kohsaka Shinichi, Nagai Yoshitaka, Seki Kazuhiko

Abstract excerpt

Age-associated neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and the polyglutamine (polyQ) diseases, are becoming prevalent as a consequence of elongation of the human lifespan. Although various rodent models have been developed to study and overcome these diseases, they have limitations in their translational research utility owing to differences from humans in brain structure and...

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PMID: 28374014
DOI: 10.1523/ENEURO.0250-16.2017
PMCID: PMC5368386

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