Article
Transgenic models of Huntington's disease.
Human molecular genetics - 1 Jan 1997
Bates G P, Mangiarini L, Mahal A, Davies S W
Abstract excerpt
CAG/polyglutamine expansion has been shown to form the molecular basis of an increasing number of inherited neurodegenerative diseases. The mutation is likely to act by a dominant gain of function but the mechanism by which it leads to neuronal dysfunction and cell death is unknown. The proteins harbouring these polyglutamine tracts are unrelated and without exception are widely expressed with extensively...
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