Article
Transgenic models of Huntington's disease.
Human molecular genetics - 1 Jan 1997
Bates G P, Mangiarini L, Mahal A, Davies S W
Abstract excerpt
CAG/polyglutamine expansion has been shown to form the molecular basis of an increasing number of inherited neurodegenerative diseases. The mutation is likely to act by a dominant gain of function but the mechanism by which it leads to neuronal dysfunction and cell death is unknown. The proteins...
Topics
- Animals
- Humans
- Huntingtin Protein
- Huntington Disease
- Mice
- Mice, Knockout
- Mice, Transgenic
- Mutation
- Nerve Tissue Proteins
- Nuclear Proteins
- Trinucleotide Repeats