Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transgenic mouse models of neurodegenerative disease caused by CAG/polyglutamine expansions.

Molecular medicine today - 1 Nov 1997

Bates G P, Davies S W

Abstract excerpt

CAG/polyglutamine expansion is the mutational mechanism that causes a number of late-onset neurodegenerative diseases. Expanded CAG repeats are unstable: they vary in size between tissues and change in size upon transmission from parent to offspring. These mutations are thought to impart a dominant gain of function to the proteins in which they are located. Recent reports describing the first mouse models of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Mice
Share to Mice, Knockout

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Pedigree

Share to Peptides

Share to Phenotype

Share to Trinucleotide Repeats

Source

Identifiers

PMID: 9430787
DOI: 10.1016/S1357-4310(97)01142-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transgenic mouse models of neurodegenerative disease caused by CAG/polyglutamine expansions.PMID 9430787Read ↗

Transgenic models of Huntington's disease.Semantic proximity Read ↗

Genetic Neurodegenerative Diseases: The Human Illness and Transgenic ModelsSemantic proximity Read ↗

Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development.Semantic proximity Read ↗

Inherited neurodegenerative diseases and transgenic models.Semantic proximity Read ↗

Relevance of Transgenic Mouse Models to Human Alzheimer DiseaseSemantic proximity Read ↗

Animal Models of Polyglutamine Diseases and Therapeutic ApproachesSemantic proximity Read ↗

Practical considerations of genetic rodent models for neurodegenerative diseases.Semantic proximity Read ↗

Transgenic animal models of neurodegeneration based on human genetic studiesSemantic proximity Read ↗

Transgenic mouse models of Alzheimer's disease.Semantic proximity Read ↗

Transgenic mouse models of Alzheimer's disease: phenotype and mechanisms of pathogenesis.Semantic proximity Read ↗

Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation.Semantic proximity Read ↗

Mouse models of triplet repeat diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.