Transgenic mouse models of neurodegenerative disease caused by CAG/polyglutamine expansions.

doi:10.1016/S1357-4310(97)01142-8

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Article

Transgenic mouse models of neurodegenerative disease caused by CAG/polyglutamine expansions.

Molecular medicine today - 1 Nov 1997

Bates G P, Davies S W

Abstract excerpt

CAG/polyglutamine expansion is the mutational mechanism that causes a number of late-onset neurodegenerative diseases. Expanded CAG repeats are unstable: they vary in size between tissues and change in size upon transmission from parent to offspring. These mutations are thought to impart a domina...

Topics

Animals
Disease Models, Animal
Humans
Huntington Disease
Machado-Joseph Disease
Mice
Mice, Knockout
Mice, Transgenic
Neurodegenerative Diseases
Pedigree
Peptides
Phenotype
Trinucleotide Repeats

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