Article

Down-Regulation of miR-212-5p Facilitates Homocysteine-Induced Hepatocytes Apoptosis Via Targeting PSMD10

2020-12-30

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Increasing evidences supported that elevated homocysteine (Hcy) levels contribute to cell apoptosis is implicated in the pathogenesis of liver injury, it correlates with liver disease severity. However, the underlying mechanism of apoptosis in Hcy-mediated liver injury remains obscure. <bold>Results: </bold>In this study, we found that homocysteine increases ER...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b6ad994e-9192-5bd7-8b2e-cb2158dda5c7
DOI: 10.21203/rs.3.rs-136080/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Down-Regulation of miR-212-5p Facilitates Homocysteine-Induced Hepatocytes Apoptosis Via Targeting PSMD10DOI 10.21203/rs.3.rs-136080/v1Read

The role of p53 in apoptosis.Semantic proximity Read

New insights into the roles of CHOP-induced apoptosis in ER stressSemantic proximity Read

Oncoprotein LAMTOR5-mediated CHOP silence via DNA hypermethylation and miR-182/miR-769 in promotion of liver cancer growthSemantic proximity Read

New insights into the roles of CHOP-induced apoptosis in ER stressSemantic proximity Read

GRP78/BiP alleviates oxLDL-induced hepatotoxicity in familial hypercholesterolemia caused by missense variants of LDLRSemantic proximity Read

HBV preS mutations promote hepatocarcinogenesis by inducing endoplasmic reticulum stress and up-regulating inflammatory signalingSemantic proximity Read

MicroRNA-362-5p promotes the proliferation and inhibits apoptosis of trophoblast cells via targeting glutathione-disulfide reductaseSemantic proximity Read

Genome-wide CRISPR screen identifies suppressors of endoplasmic reticulum stress-induced apoptosisSemantic proximity Read

Mining literature for a comprehensive pathway analysis: a case study for retrieval of homocysteine related genes for genetic and epigenetic studies.Semantic proximity Read

Effects of apoptosis on liver agingSemantic proximity Read

miR-204 Targets PERK and Regulates UPR Signaling and β-Cell ApoptosisSemantic proximity Read

The Selective Activation of p53 Target Genes Regulated by SMYD2 in BIX-01294 Induced Autophagy-Related Cell DeathSemantic proximity Read