Genome-wide CRISPR screen identifies suppressors of endoplasmic reticulum stress-induced apoptosis

Abstract excerpt

Significance Dysregulated endoplasmic reticulum (ER) stress response contributes to the pathogenesis of myriad diseases. The molecular pathways leading to ER stress-induced cell death are well characterized; however, much less is known about how cells suppress excessive ER stress response to avoid apoptosis and restore homeostasis. Using a CRISPR-based loss-of-function genetic screen, our study uncovered multiple...

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