Article

New insights into the roles of CHOP-induced apoptosis in ER stress

2015-01-29

Abstract excerpt

Endoplasmic 蜂窝胃应力(嗯应力) 在 ER 由于动态平衡的损失被触发，在 ER 腔导致累积 ofmisfolded 蛋白质。嗯因为 ER 的展开的蛋白质 response.Perturbation 是抄写因素 C/EBP 相应蛋白质(砍) 的强大的 inducer，应力激活知道的一系列适应机制。尽管它过时的人或物证明到 ER 的过多或不利的应力触发 apoptosis，由砍位于这些 processesinduced 下面的特定的机制仍然保持不清楚。现在，导致砍的 apoptosis 在嗯应力在众多的人的疾病被含有例如 neurodegenerative 疾病，糖尿病， ischemic 疾病，肿瘤等等。在这评论，我们从实验室在几疾病的发展总结了砍的角色的 currentunderstanding 到诊所。

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Literature Corpus work: 077123b5-642c-57ed-92f7-72b30f645edc
DOI: 10.1093/abbs/gmu128

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