Article

HBV preS mutations promote hepatocarcinogenesis by inducing endoplasmic reticulum stress and up-regulating inflammatory signaling

2022-01-24

Abstract excerpt

<title>Abstract</title> <p>We aimed to elucidate the effects and underlying mechanisms of hepatitis B virus (HBV) preS mutations on hepatocarcinogenesis. The association between preS mutations and hepatocellular carcinoma (HCC) occurrence was evaluated using a cohort of 2114 HBV-infected patients. Combo mutations G2950A/G2951A/A2962G/C2964A and C3116T/T31C significantly increased HCC risk in patients without anti...

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Literature Corpus work: 509bbcf5-62cb-5c14-b89e-cfb9e80ad84c
DOI: 10.21203/rs.3.rs-1231704/v1

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