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Article

The role of p53 in apoptosis.

Discovery medicine - 1 Feb 2010

Amaral Joana D, Xavier Joana M, Steer Clifford J, Rodrigues Cecília M

Abstract excerpt

The dynamic and multiple functions of p53, together with its involvement in the most common non-infectious diseases, underscore the need to elucidate the complexity of the p53 regulatory networks. Pathological conditions such as cancer, neurodegeneration, ischemia, cholestasis, and atherosclerosis are all strongly associated with deregulated levels of apoptosis in which p53 dysfunction has a prominent role. We...

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PMID: 20193641

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