Article

A cross-tissue POSTN+ fibroblast atlas links periodontal, tumor, and fibrotic stromal niches

2026-05-21

Abstract excerpt

Cross-tissue single-cell atlases have re-framed fibroblasts as a continuum of activation states, with universal Pi16+ progenitors giving rise to tissue-restricted activated populations[1] and shared pathological states recurring across inflammatory diseases[2]. Periostin (POSTN), a matricellular protein of injured, fibrotic, and tumor stroma, has been independently linked to activated fibroblasts in liver fibrosis...

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Literature Corpus work: b6a8036b-7432-5f07-bc61-5ab27170bbfe
DOI: 10.64898/2026.05.20.726414

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