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Article

DUSP7 regulates the activity of ERK2 to promote proper chromosome alignment during cell division.

The Journal of biological chemistry - 1 Jan 2000

Guo Xiao, Ramirez Ivan, Garcia Yenni A, Velasquez Erick F, Gholkar Ankur A, Cohn Whitaker, Whitelegge Julian P, Tofig Bobby, Damoiseaux Robert, Torres Jorge Z

Abstract excerpt

Human cell division is a highly regulated process that relies on the accurate capture and movement of chromosomes to the metaphase plate. Errors in the fidelity of chromosome congression and alignment can lead to improper chromosome segregation, which is correlated with aneuploidy and tumorigenesis. These processes are known to be regulated by extracellular signal-regulated kinase 2 (ERK2) in other species, but...

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Identifiers

PMID: 33865857
DOI: 10.1016/j.jbc.2021.100676
PMCID: PMC8131738

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