Article

Defining the cellular origin of seminoma by transcriptional and epigenetic mapping to the normal human germline

2024-04-25

Abstract excerpt

<h4>Summary</h4> Aberrant male germline development can lead to the formation of seminoma, a testicular germ cell tumor. Seminomas are biologically similar to primordial germ cells (PGCs) and many bear an isochromosome 12p [i(12p)] with two additional copies of the short arm of chromosome 12. By mapping seminoma transcriptomes and open chromatin landscape onto a normal human male germline trajectory, we find that...

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Literature Corpus work: b69d48f8-8739-5b1f-8b83-cdd2f954e83e
DOI: 10.1101/2024.04.20.590406

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