Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparing genome-scale DNA methylation and CNV marks between adult human cultured ITGA6+ testicular cells and seminomas to assess in vitro genomic stability.

PloS one - 1 Jan 2020

Struijk Robert B, Dorssers Lambert C J, Henneman Peter, Rijlaarsdam Martin A, Venema Andrea, Jongejan Aldo, Mannens Marcel M A M, Looijenga Leendert H J, Repping Sjoerd, van Pelt Ans M M

Abstract excerpt

Autologous transplantation of spermatogonial stem cells is a promising new avenue to restore fertility in infertile recipients. Expansion of the initial spermatogonial stem cell pool through cell culturing is a necessary step to obtain enough cells for effective repopulation of the testis after transplantation. Since in vitro propagation can lead to (epi-)genetic mutations and possibly malignant transformation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genomic Imprinting
Share to Genomic Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integrin alpha6

Share to Neoplasms, Germ Cell and Embryonal

Share to Octamer Transcription Factor-3

Share to Seminoma

Share to Testicular Neoplasms

Share to Testis

Source

Open in PubMed Open full text

Identifiers

PMID: 32176716
DOI: 10.1371/journal.pone.0230253
PMCID: PMC7075560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparing genome-scale DNA methylation and CNV marks between adult human cultured ITGA6+ testicular cells and seminomas to assess in vitro genomic stability.PMID 32176716Read ↗

Human spermatogonial stem cells and their niche in male (in)fertility: novel concepts from single-cell RNA-sequencingSemantic proximity Read ↗

Epigenetics and Testicular Cancer: Bridging the Gap Between Fundamental Biology and Patient CareSemantic proximity Read ↗

Mapping the Development of Human Spermatogenesis Using Transcriptomics-Based Data: A Scoping ReviewSemantic proximity Read ↗

Integrated molecular analysis reveals two distinct subtypes of pure seminoma of the testisSemantic proximity Read ↗

Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiationSemantic proximity Read ↗

Understanding testicular single cell transcriptional atlas: from developmental complications to male infertilitySemantic proximity Read ↗

Epigenetics and testicular germ cell tumorsSemantic proximity Read ↗

The epigenome of testicular germ cell tumorsSemantic proximity Read ↗

Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiationSemantic proximity Read ↗

Between a Rock and a Hard Place: An Epigenetic-Centric View of Testicular Germ Cell TumorsSemantic proximity Read ↗

Defining the cellular origin of seminoma by transcriptional and epigenetic mapping to the normal human germlineSemantic proximity Read ↗

Genome Wide DNA Methylation Profiles Provide Clues to the Origin and Pathogenesis of Germ Cell TumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.