Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defining the cellular origin of seminoma by transcriptional and epigenetic mapping to the normal human germline

1 Jun 2024

Abstract excerpt

Aberrant male germline development can lead to the formation of seminoma, a testicular germ cell tumor. Seminomas are biologically similar to primordial germ cells (PGCs) and many bear an isochromosome 12p [i(12p)] with two additional copies of the short arm of chromosome 12. By mapping seminoma transcriptomes and open chromatin landscape onto a normal human male germline trajectory, we find that seminoma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Protein Degradation and Inhibitors
Share to RNA Interference and Gene Delivery
Share to Testicular diseases and treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38861385
DOI: 10.1016/j.celrep.2024.114323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defining the cellular origin of seminoma by transcriptional and epigenetic mapping to the normal human germlinePMID 38861385Read ↗

Defining the cellular origin of seminoma by transcriptional and epigenetic mapping to the normal human germlineSemantic proximity Read ↗

The testicular germ cell tumour genome.Semantic proximity Read ↗

Biology and Genetics of Adult Male Germ Cell TumorsSemantic proximity Read ↗

Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors.Semantic proximity Read ↗

Evolution of Testicular Germ Cell Tumors in the Molecular Era With Histogenetic ImplicationsSemantic proximity Read ↗

Seminoma and Embryonal Carcinoma Footprints Identified by Analysis of Integrated Genome-Wide Epigenetic and Expression Profiles of Germ Cell Cancer Cell LinesSemantic proximity Read ↗

Pathogenesis and pathobiology of testicular germ cell tumours: a view from a developmental biological perspective with guidelines for pathological diagnosticsSemantic proximity Read ↗

Genome Wide DNA Methylation Profiles Provide Clues to the Origin and Pathogenesis of Germ Cell TumorsSemantic proximity Read ↗

Pathogenesis of testicular germ cell tumoursSemantic proximity Read ↗

Between a Rock and a Hard Place: An Epigenetic-Centric View of Testicular Germ Cell TumorsSemantic proximity Read ↗

Human testicular (non)seminomatous germ cell tumours: the clinical implications of recent pathobiological insightsSemantic proximity Read ↗

Origin of Subsequent Malignant Neoplasms in Patients with History of Testicular Germ Cell TumorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.